Whether rim is 16" 17" 18" 19" or 22's, you will select a tire size that is the similar diameter/width as the OE recommendations, unless you are looking for a specific look/form or function. Form might be the silly look of tiny tires for those airbag or chopped spring'd lowriders, or function from overly tall tires to go offroading with to your favorite hunting or fishing spot.
MPG should be worse with 19" wheels because OE wheels are bloated and heavy. Besides extra dead weight, the wheel/tire/rim act like a flywheel. Four heavier flywheels will lead to longer stopper distances, worse MPG, and slower acceleration.
I won't argue pothole resistance, ride quality, autocross handling... as that is for the owner to decide and will also depend on the quality/rating of the tire. I do like my taller sidewalls and smaller diameter rims for ride quality and pothole resistance.
What are your OE sizes and diameters so that you can see the range that is acceptable by the automaker?
Not responsible for typos but you can figure it out with the calculator link above:
I'd wager that some might like the look of 22's if those owners could find a set of wheels that match their teeth or piercings. 245/30-22 = 27.8"
Tire brand/type, PSI, load rating... would also make a ride quality, MPG, ... change. Regardless of the width, the footprint will depend on load rating and PSI. And, different size tires, and different load rated tires, will require a different PSI than what is recommended by the automaker to mimic that footprint to avoid any MPG, traction increase/decrease, ride quality changes... PSI matching for tire size changes, or load rating changes, isn't understood by tire shops or 99.9% of consumers and forum members.
You can lead a horse to water, but you can't make it drink.